Jun Li;William Shannan O'Shaughnessy;Trevor Squier;Michael Bouchard;Christopher R. Loose;Chad Huval;Zheng Zhang;Michael Hencke
发明人:
Jun Li,Trevor Squier,Zheng Zhang,Chad Huval,William Shannan O'Shaughnessy,Michael Hencke,Michael Bouchard,Christopher R. Loose,William Shannan OShaughnessy
申请号：
US12632686
公开号：
US09895470B2
申请日:
2009.12.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
