Robert Fishman,Robert Havener,Ihab A. Fattah,Anas Abdelazim,Scott Newell,Thomas H. Bishop,Tamer I. Khayal,Stanley Kyi,Ron Taylor, Jr.,Doug Harriott,Matthew De Remer,Paul Murray,John Sullivan,Mark Ande
申请号：
US13765009
公开号：
US09516875B2
申请日:
2013.02.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit； circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface； and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
