COMBINATION THERAPY USING PDK1 AND PI3K INHIBITORS

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专利权人:

MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人:

CASTEL, PAU,BASELGA, JOSE T.,SCALTRITI, MAURIZIO

申请号：

CA2992945

公开号：

CA2992945A1

申请日:

2016.07.15

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to methods and compositions for inhibiting growth and proliferation of cancer cells resistant to PI3K inhibition using a combination of PDK1, SGK1 and PI3K inhibitors. The present invention is also directed to methods of treating cancer in a subject exhibiting cancer cells resistant to PI3K inhibition, comprising administering inhibitors of PI3K in combination with inhibitors of PDK1 and/or SGK1 to the subject.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/