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6,7-dihydro-5h-benzo[7]annulene derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and the use thereof for production of medicaments
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
KOSEMUND DIRK,WINTERMANTEL TIM,MÖLLER CARSTEN,BOTHE ULRICH,NUBBEMEYER REINHARD,ZORN LUDWIG,TER LAAK ANTONIUS,BOHLMANN ROLF,WORTMANN LARS,BIERER DONALD
申请号:
NZ60506111
公开号:
NZ605061A
申请日:
2011.06.21
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed are compounds of formula (I) that have a cycloheptene ring fused with benzene ring to form a substituted 5-H benzo-[7]annulene compound. The substituents are as disclosed in the specification. The disclosure relates to selective estragon receptor modulators (SERMs) and to processes for production thereof, to the use thereof for treatment and/or prophylaxis of disorders, and to the use thereof for production of medicaments for treatment and/or prophylaxis of disorders, more particularly of bleeding disorders, osteoporosis, endometriosis, myomas, hormone-dependent tumours, for hormone replacement therapy and for contraception. Examples of compounds of formula (I) are: 8-(3,4-Difluorophenyl)-9-{ 6-[(3-methoxypropyl) (3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl} amino]hexyl} -6,7-dihydro-5H-benzo[7]annulen-3-ol; 4-Fluoro-8-(4-fluorophenyl)-9-[6-(methyl{ 3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl} amino)hexyl]-6,7-dihydro-5H-benzo[7]annulen-3-ol and 4-Fluoro-8-(4-fluorophenyl)-9-[6-(methyl{ 3-[(3,3,4,4,4-pentafluorobutyl)sulphonyl]propyl} amino)hexyl]-6,7-dihydro-5H-benzo[7]annulen-3-ol.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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