NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE&, TECHNOLOGY
发明人:
MATSUO YUKITAKE,MATSUMURA TAKESHI
申请号：
JP20080222961
公开号：
JP2010051297(A)
申请日:
2008.08.30
申请国别(地区):
日本
年份:
2010
代理人:
摘要：
<p><P>PROBLEM TO BE SOLVED: To provide a method for reducing or inhibiting the modification of an N-linked sugar chain with fucose in a plant, a transgenic plant in which the fucose modification is reduced or inhibited, and others. <P>SOLUTION: The amount of GDP-fucose in a plant cell is reduced by inhibiting the transcription/translation of a gene encoding an enzyme involved in the synthesis of a sugar nucleotide GDP-fucose through posttranscriptional gene silencing (PTGS), virus-induced gene silencing (VIGS) or transcriptional gene silencing (TGS). In this manner, the modification of a sugar chain such as a glycoprotein sugar chain, a glycolipid sugar chain, an oligosaccharide or a polysaccharide with fucose is reduced or inhibited, thereby producing a glycoprotein or the like in which a fucose-modified part, which can act as an allergen, is removed. It becomes possible to use a medical glycoprotein produced in a plant for clinical purposes. <P>COPYRIGHT: (C)2010,JPO&INPIT</p>
