INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS
发明人:
CHO, Yong Woo,조용우,CHOI, Ji Suk,최지숙,WOO, Chang Hee,우창희,CHOI, Young Chan,최영찬,JO, Dong Gyu,조동규
申请号：
KRKR2016/001230
公开号：
WO2016/126122A2
申请日:
2016.02.04
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to: a composition for chondrocyte differentiation induction or cartilage tissue regeneration, containing, as active ingredients, exosomes extracted from stem cells differentiating into chondrocytes a medium composition for chondrocyte differentiation induction, an injection for cartilage tissue regeneration, and a pharmaceutical composition for treating cartilage disorders, all of which contain the composition and a method for treating cartilage disorders. According to one specific embodiment of the present invention, the composition for chondrocyte differentiation induction or cartilage regeneration contains, as active factors, exosomes extracted from stem cells differentiating into chondrocytes. Exosomes to be secreted during stem cell differentiation contain growth factors associated with chondrocyte differentiation, and genes and proteins associated with stem cell proliferation and regeneration, and thus the induction of damaged cartilage tissue regeneration is excellent. In addition, an active material can be stably and rapidly delivered as a cell-derived vehicle into cells while side effects on a conventional cell therapeutic agent are minimized. Therefore, a patients pain can be reduced through a simple operation by means of an injection composition for preventing and treating cartilage disorders, and cartilage disorders can be continuously and effectively treated after an operation.La présente invention se rapporte à : une composition pour induction de différenciation de chondrocyte ou régénération de tissu cartilagineux, contenant, en tant quingrédients actifs, des exosomes extraits de cellules souches se différenciant en chondrocytes une composition de milieu pour induction de différenciation de chondrocyte, une injection pour régénération de tissu cartilagineux, et une composition pharmaceutique pour le traitement de troubles des cartilages, dont toutes contiennent la composition et un procédé pour le traitement de troubles
