FLT3及CD3抗體構築體农业专利-农业学术服务平台

发明人:: RAUM, TOBIAS,瑞乌　托拜耳斯,瑞烏　托拜耳斯,PENDZIALEK, JOCHEN,潘兹亚雷克　乔恩,潘茲亞雷克　喬恩,BLUEMEL, CLAUDIA,布鲁梅尔　克劳蒂亚,布魯梅爾　克勞蒂亞,BOTT, FRANZISKA,波特　法兰西斯卡,波特　法蘭西斯卡,DAHLHOFF, CHRISTOPH,达霍夫　克里斯多夫,達霍夫　克里斯多夫,HOFFMANN, PATRICK,霍夫曼　派,瑞乌托拜耳斯,瑞烏托拜耳斯,潘兹亚雷克乔恩,潘茲亞雷克喬恩,布鲁梅尔克劳蒂亚,布魯梅爾克勞蒂亞,波特法兰西斯卡,波特法蘭西斯卡,达霍夫克里斯多夫,達霍夫克里斯多夫,霍夫曼派

摘要：: The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.本發明係關於一種雙特異性抗體構築體，其包含結合於目標細胞表面上之人類FLT3的第一結合域及結合於T細胞表面上之人類CD3的第二結合域。此外，本發明提供一種編碼該抗體構築體之聚核苷酸、包含該聚核苷酸之載體，及用該聚核苷酸或載體轉型或轉染之宿主細胞。此外，本發明提供一種用於產生本發明之抗體構築體的方法、該抗體構築體之醫療用途，及包含該抗體構築體之套組。