Bioinicia, S.L.;ZF Polpharma S.A.;Consejo Superior de Investigaciones Científicas (CSIC)
发明人:
申请号：
EP18382484.6
公开号：
EP3586827A1
申请日:
2018.06.29
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical formulation comprising at least one active pharmaceutical ingredient (API) having low aqueous solubility or a pharmaceutically acceptable salt thereof in the form of particles of a size between 1 and 800 nm, wherein said particles are encapsulated within a large microparticle of a size between 1 and 100 µm formed by a matrix comprising at least an excipient.. Therefore, the API is entrapped or encapsulated in the microparticles of excipients. This pharmaceutical formulation contains the pharmaceutical active ingredient having improved solubility and subsequently supra-bioavailability.
