Surgical clips, clip appliers, and applications thereof, configured for controlled deployment of the clips in a subjects body. The clips and clip appliers are shiftable through several configurations, including a stowed configuration in which clip arms are in proximity and unlocked, a deployed configuration in which clip arms are distant and become lockable, and a locked configuration in which the clip arms are in proximity and locked. In exemplary embodiments, a first clip arm adjoins the other with a flexible extension, optionally curved with an inflection point, and the other clip arm adjoins the first clip arm with a rigid extension. A clip interconnecting mechanism for connecting to another clip may be configured for autonomous release when ejecting from the clip applier.
