Process for the manufacture of epoxybutanol intermediates

• 收藏
• 分享

专利权人:

Basilea Pharmaceutica AG

发明人:

Xu, Lin,Muller, Marc

申请号：

AU2010203301

公开号：

AU2010203301B2

申请日:

2010.07.23

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2010203301B220120621.pdf#####PROCESS FOR THE MANUFACTURE OF EPOXYBUTANOL INTERMEDIATES Abstract Disclosed is process for the manufacture of a compound of formula (IV-a) 67 wherein PrG represents a hydroxyl protecting group in which process 1,4-difluorobenzene is reacted in the presence of a base with a compound of formula (Ill-a) wherein PrG has the same meaning as in formula (IV-a), R3 represents methyl or ethyl, and R4 represents methyl, ethyl or methoxy, or R3 and R4 taken together with the nitrogen atom to which they are bound represent a 4- to 6-membered /0 heterocyclic group having either no or one or two further heteroatoms selected from nitrogen or oxygen. O OPrG F 0 OPrG F (IV-a) R3 R4 (Ill-a) (2847569 1):KZA

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/