The present invention provides a left atrial appendage occluder and a manufacture method thereof, wherein the left atrial appendage occluder comprises a nitinol meshed bracket having a tubular shape and being provided with a left disk and a right disk at two ends of the nitinol meshed bracket, respectively； the left disk and the right disk are connected by a mobile portion, the left disk and the right disk are provided with a resistance membrane, respectively. The manufacture method of the left atrial appendage occluder comprises steps of weaving a elongated web, then performing pre-heat treatment, shaping, and final-heat treatment, etc., to accomplish the manufacture of the left atrial appendage occluder. The present invention is simple in structure, convenient in use, and can simplify the operation process, and shorten the operation time. Meanwhile, the present invention is no need for X-ray to perform the left atrial appendage occlusion surgery, which greatly reduces the damage to both the doctor and patient. Moreover, the left atrial appendage occluder manufactured by the manufacture method of the present invention has good performance, and is reliable in operation.
