This invention relates to a topical gel drug product preparation containing a composition comprising an isolated polypeptide having a carboxy terminal amino acid sequence of an alpha connexin (ACT peptide) peptide stabilizers excipients buffering agents and the like. A formulation and preparation steps are disclosed for the manufacturing of a stable elegant and pourable topical gel. The resulting formulation possesses long term stability suitable for aesthetic as well as therapeutic applications including the prevention of scaring and accelerated healing of wounds.