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Derivatives of 4 - (5 - cyano - pyrazol-1-yl) - piperidine as modulators of GPR119
- 专利权人:
- PFIZER INC.
- 发明人:
- VINCENT MASCITTI,RALPH PELTON ROBINSON,KIM FRANCIS MCLURE,MICHAEL JOHN MUNCHHOF
- 申请号：
- ARP110104351
- 公开号：
- AR088121A1
- 申请日:
- 2011.11.22
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要：
- Compounds that modulate the activity of GPR119 G Protein coupled receptor and their uses for the treatment of diseases related to the Modulation of GPR119 G Protein coupled receptor in animals.Claim 1 is characterized in that: a compound selected from the group consisting of: 4 - (5 - cyano - 4 - [(2,4 - difluorofenoxi) methyl] - 1H pyrazole IL - 1 - 1} piperidin - carboxylate； isopropyl 4 - {5 - cyano - 4 - [(2 - metilfenoxi) methyl] - 1H pyrazole IL - 1 - 1} piperidin - carboxylate； isopropyl 4 - {5 - cyano - 4 - [(25 - difluorofenoxi) methyl] - 1H pyrazole IL - 1 - 1} piperidin - carboxylate metilciclopropilo {1 -, 4 -, 5 - cyano - 4 - [(23 - difluorofenoxi) methyl] - 1H pyrazol-1-yl piperidin - carboxylate} 1 - {1 metilciclopropilo； 4 - [4 - (4 - carbamoyl - 2 - fluorofenoxi) methyl] - 5 - cyano - 1H pyrazol-1-yl piperidin} 1 - 1 - metilciclopropilo carboxylate； 4 - (4 - ((4 - carbamoilfenoxi) methyl] - 5 - cyano - 1H pyrazol-1-yl piperidin} 1 - 1 - metilciclopro carboxylate Pilo； 4 - (5 - cyano - 4 - ((4 - cianofenoxi) methyl) - 1H pyrazol-1-yl) piperidin 1 - 1 - metilcicloprop carboxylateILO； 4 - (4 - ((4 - (1H - pyrazol-1-yl) phenoxy) methyl) - 1H - 5 - cyano - pyrazol-1-yl) piperidin 1 - carboxylate； isopropyl 4 - (5 - (4 - (cyano 2-fluoro-4 - (1h tetrazole - 5 - il) phenoxy) methyl) - 1H pyrazol-1-yl) piperidin - carboxylate and 1 isopropyl 4 - (5 - (4 - (cyano 2-fluoro-4 - (2h-tetrazol-5-yl) phenoxy) methyl) - 1H pyrazole - 1 - il) PIP Eridin - 1 - carboxylate； isopropyl 4 - (5 - (4 - (cyano 2-fluoro-4 - (1 - methyl - 1h-tetrazol-5-yl) phenoxy) methyl)- 1H pyrazol-1-yl) piperidin 1 - carboxylate； isopropyl 4 - (5 - (4 - (cyano 2-fluoro-4 - (2 - methyl - 2h-tetrazol-5-yl) phenoxy) methyl) - 1H pyrazol-1-yl) piperidin - 1 carboxylate； isopropyl 4 - (5 - (4 - (cyano 2-fluoro-4 - (2 - (2-hydroxyethyl) - (2h-tetrazol-5-yl) phenoxy) methyl) - 1H pyrazol-1-yl) piperidin - carboxylate 1 ISO Propyl； 4 - (5 - (4 - (cyano 2-fluoro-4 - (1 - (2-hydroxyethyl) - (1h-tetr
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
