This application obstructs JNK, formula I and II (in formula, as for R and R, that it stated in bill, it is synonymous,) new pirimijinirupiridon derivative is disclosed. Although the chemical compound which is disclosed in this bill adjusts the activity of JNK, deals with the disease which it is related to excessive JNK activity it is useful. Chemical compound, the autoimmune disease and the inflammation characteristic disease, metabolism obstacle, is useful in the nervous disease, and disposal of the cancer. The chemical compound of formula I of the composition and the remedy effective quantity which include the chemical compound of formula I also the treatment method of including the fact that it prescribes to the object which needs that is disclosed.本出願は、JNKを阻害する、式IおよびII(式中、R1およびR2は、明細書に記載したと同義である)の新規なピリミジニルピリドン誘導体を開示している。本明細書に開示されている化合物は、JNKの活性を調節し、過剰なJNK活性に関連する疾患を処置するのに有用である。化合物は、自己免疫疾患、炎症性疾患、代謝障害、神経疾患、および癌の処置に有用である。式Iの化合物を含む組成物および治療有効量の式Iの化合物をそれを必要とする対象に投与することを含む処置方法をも開示している。
