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Compounds as bradykinin b1 antagonists
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
DOODS HENRI,MACK JUERGEN,KONETZKI INGO,PRIEPKE HENNING,HAUEL NORBERT,WIEDENMAYER DIETER,WALTER RAINER,CECI ANGELO,SCHULER-METZ ANNETTE
申请号:
NZ59467410
公开号:
NZ594674A
申请日:
2010.02.23
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
594674 Disclosed herein is a family of compounds of general formula (I) where n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are as defined in the specification. The disclosure also relates to enantiomers, diastereomers, mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases. The disclosed family of compounds may be suitable for treating disease and symptoms of diseases associated with the stimulation of bradykinin-B1 receptors, including acute pain, visceral pain, neuropathic pain, inflammatory pain, tumour pain and headaches. As such, the disclosure also relates to the preparation of medicaments containing these compounds. Examples compounds of general formula (I) include: 5-amino-N-(1-{ [5-(4-bromo-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl} -cyclopropyl)-nicotinamide pyrimidine-5-carboxylic acid-(3-{ 1-[5-(4-bromo-2-trifluoromethyl-phenylamino)-pyridin-2-yl]-ethylcarbamoyl} -(S)-tetrahydro-furan-3-yl)-amide 4-{ 6-[({ 1-[(pyrimidine-5-carbonyl)-amino]-cyclopropanecarbonyl} -amino)-methyl]-pyridin-3-ylamino} -3-trifluoromethyl-benzoic acid 2-amino-1H-benzimidazole-5-carboxylic acid-(1-{ [5-(4-chloro-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl)-carbamo} -cyclopropyl)-amide (S)-3-[(tetrahydro-furan-3-carbonyl)-amino]-tetrahydro-furan-3-carboxylic acid-4-(2-trifluoromethyl-phenylamino)-benzylamide
来源网站:
中国工程科技知识中心
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