The present disclosure pertains to a system to configure respiratory therapy modes for users of respiratory therapy devices. The system comprises processors configured to execute computer program modules comprising: a data gathering module for receiving usage information related to a respiratory therapy device in a first therapy mode； an analysis module for determining effectiveness information related to effectiveness of therapy； a provider interface module configured for receiving a first unlock selection based on the determined effectiveness information, the first unlock selection being received while the respiratory therapy device is operating in the first therapy mode, the first unlock selection indicating that a second therapy mode for the respiratory therapy device should be unlocked； and a device configuration module configured such that, responsive to reception of the first unlock selection by the provider interface module, the device configuration module activates the second therapy mode for the respiratory therapy device.
