abstract this invention relates to methods that provide immunosuppressants and therapeutic macromolecules that are administered within a pharmacodynamically effective window of the immunosuppressants to induce immune tolerance to the therapeutic macromolecules. the methods allow shifting the immune response in favor of tolerogenic immune response development specific to the therapeutic macromolecule. ______________ Translation of the Summary Patent Summary: "Delivery of immunosuppressants that have a specified pharmacodynamic effective life and antigen for the induction of immune tolerance". The invention relates to methods which provide therapeutic immunosuppressants and macromolecules that are administered within a pharmacodynamically effective time frame as immunosuppressants to induce immune tolerance to therapeutic macromolecules. The methods allow redirecting the immune response in favor of the development of a specific tolerogenic immune response to the therapeutic macromolecule.abstract this invention relates to methods that provide immunosuppressants and therapeutic macromolecules that are administered within a pharmacodynamically effective window of the immunosuppressants to induce immune tolerance to the therapeutic macromolecules. the methods allow shifting the immune response in favor of tolerogenic immune response development specific to the therapeutic macromolecule. ______________ tradução do resumo resumo patente de invenção: "entrega de imunossupressores que têm uma vida eficaz farmacodinâmica especificada e antígeno para a indução de tolerância imunológica". a invenção refere-se a métodos que fornecem imunossupressores e macromoléculas terapêuticas que são administrados em um intervalo de tempo farmacodinamicamente eficaz quanto aos imu-nossupressores para induzir tolerância imunológica às macromoléculas terapêuticas. os métodos permitem redirecionar a resposta imunológica a favor do desenvolvimento de uma resposta imunológica tolerogênica específ
