A manually operated multiple pill or tablet splitter for simultaneously cutting or splitting a plurality of pills in a single operation is disclosed. The device includes a base member that provides a flat top surface for loading the pills, spring loaded alignment bars for containing, aligning, and holding the pills or tablets in a straight line, and a close fitting cover member having a cutting blade fitted inside which is surrounded by a retractable spring biased blade guard to cover the blade prevent injury. When the cover is manually pushed down onto the base member, the blade guard is retracted and the cutting blade bisects all the pills or tablets in a single operation.