JU, JUNG WON,주정원,CHO, SHIN HYEONG,조신형,LEE, WON JA,이원자,CHUNG, EUN JOO,정은주,LEE, MYOUNG RO,이명노,JEONG, YOUNG IL,정영일,JU, JUNG WONKR,CHO, SHIN HYEONGKR,LEE, WON JAKR,CHUNG, EUN JOOKR,LEE, MYOUNG ROKR,JEONG, YOUNG ILKR
申请号：
KR1020140070053
公开号：
KR1015539740000B1
申请日:
2014.06.10
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a composition for inhibiting an aggregation phenomenon of a protein comprising a heat shock recombinant protein CsHSP70 derived from Clonorchis sinensis of SEQ ID NO: 1 as an active ingredient and, particularly, to a composition for inhibiting protein aggregation inhibiting an aggregation phenomenon in a process of exchanging a buffer solution or the like during expression and purification of a non-aqueous recombinant protein, capable of inhibiting a protein aggregation inhibition phenomenon in a process of separation and purification of a recombinant protein.본 발명은 서열번호 1의 간흡충(Clonorchis sinensis) 유래 열충격 재조합 단백질 CsHSP70을 유효성분으로 포함하는 단백질의 응집현상을 저해하는, 특히 비수용성 재조합 단백질 발현, 정제 시 완충용액 교환 과정 등에서 응집현상을 저해하는 단백질 응집 저해용 조성물에 관한 것으로서, 재조합 단백질의 분리 및 정제과정에서 단백질 응집 저해현상을 억제할 수 있다.
