Daniel Tracey;Stuart F;Boris Labkovsky;Jochen Salfeld;Michael Roguska;Michael White;Geertruida M. Veldman;Michael Paskind;Paul Sakorafas;Amy Venturini;Zehra Kaymakcalan;Subhashis Banerjee;Angela Widom
发明人:
Jochen Salfeld,Michael Roguska,Michael Paskind,Subhashis Banerjee,Daniel Tracey,Michael White,Zehra Kaymakcalan,Boris Labkovsky,Paul Sakorafas,Geertruida M. Veldman,Amy Venturini,Angela Widom,Stuart F
申请号：
US13401559
公开号：
US09035030B2
申请日:
2012.02.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
