Binnaz K. Staley,Fei Xie,Lucas Horan,Yiyang Xu,Javier Morales,Hong Liu
申请号：
US16637524
公开号：
US20200255505A1
申请日:
2018.08.08
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides a cell comprising (a) a nucleic acid comprising a first nucleotide sequence encoding a cell surface receptor comprising an extracellular domain (ECD) which binds to a first target, a transmembrane domain (TMD), and an intracellular domain (ICD) comprising at least a portion of a T-cell signaling molecule, and (b) a nucleic acid comprising a second nucleotide sequence encoding an antigen-binding protein which binds to a second target and a third target, wherein the second nucleotide sequence is operably linked to an inducible promoter, wherein expression of the second nucleotide sequence is activated upon binding of the first target to the cell surface receptor. Related compositions, kits, articles of manufacture, and methods are further provided.
