PEI, TAO,KANNER, STEVEN B.,ZHU, RUI,MELQUIST, STACEY,ALMEIDA, LAUREN J.,LI, ZHEN
申请号：
CA3048661
公开号：
CA3048661A1
申请日:
2018.01.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
RNA interference agents for inhibiting the expression of Factor XII ( FXII) gene are described. Pharmaceutical compositions comprising one or more FXII RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo are also described. Delivery of the FXII RNAi agent(s) to liver cells in vivo provides for inhibition of FXII gene expression and treatment of angioedema. including hereditary angioedema ( HAE) and venous thromboembolism (VTE). and diseases associated with angioedema.
