AMANS Dominique,АМАНС Доминик,BAMBOROUGH Paul,БАМБОРО Пол,BARKER Michael David,БАРКЕР Майкл Дейвид,BIT Rino Antonio,БИТ Рино Антонио,BROWN John Alexander,БРАУН Джон Александер,CAMPBELL Matthew,КАМПБЕЛ
申请号：
RU2015137103
公开号：
RU0002655727C9
申请日:
2014.03.12
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to novel furopyridine derivatives of formula Iwhere: V is N or C-R2 W is N or C-R8 X is N, CH or C(CH3) Y is N or C-R5 Z is N or C-R15 Q is N or CH R1 is C1-4alkyl or deuterated C1-4alkyl R2, when present, is H, OH, -NH2, -OC1-4alkyl, -NHC(O)H, -NHC(O)C1-4alkyl, -H(CH3)C(O)C1-4alkyl, -NHC(O)NH2, -NHC(O)C1-4alkyleneNH2, -N(CH3)C(O)NH2, -N(CH3)C(O)C1-4alkyleneNH2, -OC2-4alkyleneOCH3, -OC2-4alkyleneOH or R2 is a group selected from -G-CH2CH(R3)(R4), -G-CH(R3)(R4) and -G-R3, in which G is NH, N(CH3), O, C(O)NH or NHC(O) R3 is phenyl, pyridinyl, C3-7cycloalkyl or a 5-6 membered heterocycle containing an oxygen or nitrogen atom and optionally substituted with =O and R4 is H or C1-4alkyl R5, when present, is H, OH, -OC1-4 alkyl, -CH2NH2, -OCF3, -C(O)NHC1-4alkyl or -CO2H R6 is -NR11R12 or groupD is CH or N E is N, O, CH or SO2 R7, when present, is H, OH, C1-4 alkyl, -SO2C1-4alkyl, -NHSO2CH3, -C(O)C1-4alkyl R8, when present, is H, C1-4 alkyl, OH, -OC1-4 alkyl, -OC2-4alkyleneOC1-4 alkyl, -OCF3 -OC1-4alkyleneF, -OC1-4alkyleneCHF2, -OC2-4alkyleneOH, -Ophenyl, -OC1-4alkylenephenyl, -NHC3-7cycloalkyl, -NHC1-4alkylene C3-7cycloalkyl, -OC3-7cycloalkyl, -OC1-4alkyleneC3-7cycloalkyl, -NHC4-6heterocycle, -NHC1-4alkyleneC4-6heterocycle, -OC4-6heterocycle or -OC1-4alkylene C4-6heterocycle, containing as a heteroatom N or O, where each C3-7cycloalkyl or C4-6heterocycle is optionally substituted with one or two substituents independently selected from halogen and oxo or R8 and R2 together with the carbon atoms to which they are attached form a heterocycle containing as a heteroatom N and optionally substituted oxo R9 is H, C1-4alkyl, halogen, OH, -OC1-4alkyl, -CH2OH, -C(O)NHCH3, -C(O)NH(CH3)2 R10 is H, C1-4alkyl, halogen, OH, -OC1-4alkyl or oxo R11 is H, C1-4alkyl or SO2CH3 R12 is H, C1-4alkyl, C2-4alkyleneNHR13, SO2CH3, a 5-6 membered heterocycle containing SO2 R13 is H or SO2CH3 R14 is H or C1-4alkyl R15 is H, C1-4alkyl or NHC(O)C1-4alkyl R1
