The present invention relates to a system for the prevention of needle tract tumor cell seeding, comprising a percutaneous surgical instrument (1) with a distal part percutaneously introducible into a tissue (3) of a patient an electric current generator (2) generating current with at least one direct current component with a first terminal (2a) connected to the proximal end (1a) of the instrument (1) and a second terminal (2b) connected to an electrode (4) applied to the skin of the patient, such that the instrument (1) acts as the first electrode, the contact electrode (4) acts as the second electrode and the tissue (3) acts as the electrolyte the electric current generator (2) is capable of inducing a transient circulation of the current with the direct current component, between the part of the instrument (1) introduced into the tissue and the contact electrode (4), resulting in one of an average current density, measured on the surface in the percutaneously introducible part of the instrument (1), of at least a chosen current density in the range between 1 mA/cm2 and 1000 mA/cm2 for circulation periods between 0.1 seconds and 10 minutes, such that the product of the average current density by time is greater than 50 mA.s/cm2 and less than 10000 mA.s/cm2, for generating electrochemical reactions producing a sufficiently toxic microenvironment (5) in the tissue (3) around the part of the instrument (1) introduced into the tissue of the patient.La présente invention concerne un système de prévention de lessaimage de cellules tumorales au niveau dun orifice de perforation daiguille, ledit système comprenant un instrument chirurgical percutané (1) dont une partie distale peut être introduite de façon percutanée dans un tissu (3) dun patient un générateur de courant électrique (2) qui génère un courant avec au moins une composante de courant continu, et doté dun premier terminal (2a) connecté à lextrémité proximale (1a) de linstrument (1) et dun second terminal (2b)
