The invention relates to a Laser system (1) for irrigation, including debriding, cleaning and decontamination, of anatomical cavities (2) filled with a liquid (3). The laser system (1) comprises a laser source (4) for generating a laser beam (5), and an optical delivery system (6) for the laser beam (5), wherein the delivery system (6) includes a treatment handpiece (7) and an exit component (8). The treatment handpiece (7) and the exit component (8) are configured to irrigate the anatomical cavity (2). A wavelength of the laser beam (5) is in a range from above 0.4 µm to 11.0 µm inclusive. The laser system (1) is adapted to be operated in pulsed operation with pulse sets (21) containing at least two and maximally twenty individual pulses (p) of a temporally limited pulse length (tp), wherein a temporal separation (ts) between the pulse sets is ≥ 20 ms, and wherein the individual pulses (p) follow one another with a temporal pulse period (TP) within a range of 50 µs, inclusive, to 1000 µs, inclusive. The laser system (1) further comprises a feedback system (9) to determine a bubble oscillation intensity of at least one vapor bubble (18) generated within the liquid (3) when irradiated with the laser beam (5). Adjusting means (10) are provided for adjusting the temporal pulse period (TP) to achieve at least approximately a bubble oscillation intensity maximum.
