The General Hospital Corporation;Naar, Anders M.;Rajurkar, Mihir Shivadatta
发明人:
申请号：
EP15811533.7
公开号：
EP3161159B1
申请日:
2015.06.25
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.
