LAIRD BLOOM,DAVINDER GILL,YULIA VUGMEYSTER,DEBORAH A YOUNG,MARGOT O TOOLE,HEATH M GUAY,KARISSA K ADKINS,AMY ARLENE WEAVER,SADHANA JAIN,MAYA ARAI
申请号：
IN9144/DELNP/2010
公开号：
IN2010DN09144A
申请日:
2010.12.22
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
