The present invention relates to a composition for treating or preventing cancers. More specifically, the present invention relates to a fusion protein bound to annexin a1 binding protein, p53 protein, and p18 protein or p16 protein a manufacturing of the fusion protein and a composition for treating and preventing cancers including the fusion protein. In the present invention, the fusion protein comprises at least one polypeptide selected from a group consisting of in vitro stabilization protein, a membrane transfer sequence domain (MTS), a nucleus-cytoplasm signal domain and in vivo stabilization protein.COPYRIGHT KIPO 2015아넥신 A1 결합단백질, p53 단백질, 및 p18 또는 p16 단백질이 결합된 융합 단백질, 상기 융합 단백질의 제조, 및 상기 융합 단백질을 포함하는 암의 예방 또는 치료용 약학 조성물에 관한 것이다.
