A therapeutic material or pharmaceutical is composed of 1) amniotic membranes in a large intact sheet, 2) lysates of intact sheets of amniotic membrane, or 3) the non-particulate fluids produced while creating lysates of intact sheets of amniotic membrane. Any of the embodiments of the therapeutic material can be formed with or without the incorporation of complex chemicals like hyaluronic acid and/or honey and/or additional therapeutic cells. The device or fluid is used to treat diseased tissue. Lysates of the amniotic membrane can be formed into any desirable shape, and then dehydrated, to maintain the desired 3D form of the device.