재단법인대구경북과학기술원;DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
KIM, HYUN CHUL,김현철,JEONG, SANG WON,정상원,KIM, EUN JOO,김은주,LEE, SE GUEN,이세근,LEE, SUNG JUN,이성준
申请号：
KR1020110120209
公开号：
KR1020130054676A
申请日:
2011.11.17
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and poly&lsqb；N-2-(hydroxypropyl)methacrylamide&rsqb；. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.내부에 약물이 봉입함으로써 약물의 독성으로 인한 부작용을 최소화 하고, 약물의 용해도를 증가시켜 치료 효과를 극대화 하며, 다양한 생리 조건에서 균일한 구형 구조를 유지함으로써 체내 안정성을 유지할 수 있는, 약물 전달체를 제공한다.
