1. Claim 1: a formula (1), wherein X is C (o) or so 832222；And from - ch8322 -,-CH=CH---C (CH) --CH (CH) --CH₂CH₂,-Ch (OH)-N 3DCH- o -C (O) -R¹ is (3,3-dimethylbutan-2-yl) or C₁₋₄ alkyl,wherein said C₁₋₄-alkyl is optionally substituted with cyclopropyl and 0, 1, 2 or 3 F； R² is selected from CH₃,NHR830808,a. Methyl (1-methyl-1h-pirazol-5-il)； R3 (2) was selected from the formula group；R8308es C (o) ch 8323 or so8322； r8310；R83099 was selected from (3-cyanofen) sulfur, ch832323；N (CH)NH.8322；NHCH₂CF₃,NH (oxetan-3-ilo)NH-alkyl Cilo,a. Where c83321c833318323 apartment is replaced, 0-3f and 0-1 independently selected substitutes can be used instead of 0-838323 apartment；cyclopropyl or NH-cycloalkyl C₃₋₄,wherein said cycloalkyl may be substituted with 0-2 F； R⁶ is selected from cyclopropyl, (1,3-dimethyl-1H-pyrazol-4-yl) methyl or C₁₋₄ alkyl,a. Among c833216c833383248 substitutes, 0-1 substitutes were selected instead of 0-838323；NCH 832323 o cyclopapilo； r831111 selected from h, CL or ch832323；R831222 from - NH (C = O) ch8323；Or by a set of formulas (3)；R8313 is selected from h, CL or n832222；R1 830404 was selected from Ho nh832222；R1 is selected from C (o) nh482222；C (o) nhch8323o C (o) nhch832222-phenyl； R 2 from co8322； h, co8322； ch8322； ch832323o co8322； (NH (CH 8322223) 832nh22；R3: selected from H or ch832323；And selected from n or CH； or from a salt acceptable to the drug.Reivindicación 1: Un compuesto de fórmula (1) en donde X es C(O) o SO₂； Y se selecciona de -CH₂-, -CH=CH-, -C(CH₂)-, -CH(CH₃)-, -CH₂CH₂, -CH(OH)-, -N=CH- o -C(O)-； R¹ es (3,3-dimetilbutan-2-ilo) o alquilo C₁₋₄, en donde dicho alquilo C₁₋₄ está opcionalmente sustituido con ciclopropilo y 0, 1, 2 ó 3 F； R² se selecciona de CH₃, NHR⁴, SO₂R⁵ o (1-metil-1H-pirazol-5-il)metilo； R³ se selecciona de los compuestos del grupo de fórmulas (2)； R⁴ es C(O)CH₃ o SO₂R⁶； R⁵ se selecciona de (3-cianofenil)sulfamoílo, CH₃, N(CH₃)₂, NH₂, NHCH₂CF₃, NH(oxetan-3-ilo), NH-alquilo C₁₋₃, en donde dicho alquilo C₁₋₃ está
