Christoph Marcel Tang,Susan Mary Lea,Ilse Jongerius,Hayley Lavender
申请号：
US14776229
公开号：
US20160030544A1
申请日:
2014.03.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides an immunogenic composition capable of eliciting an immune response when administered to a human or non-human animal, wherein the composition comprises an isolated protein with one or more of the following properties: i) about 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 or more percent sequence identity to the protein of SEQ ID No: 1 or a fragment, derivative or analog thereof ii) is a modified factor H binding protein, wherein the factor H binding protein has been modified at least at the position equivalent to position 318 as defined in FIG. 6 (SEQ ID No: 2) iii) does not bind to factor H and iv) the immune response elicited is cross reactive with two or more of variant 1 factor H binding protein, variant 2 factor H binding protein and variant 3 factor H binding protein from N. meningitidis and uses thereof.
