Parasuraman Jaisankar,Snehasikta Swarnakar,Sourav Chatterjee,Sugreev Verma,Madhumita Mandal,Susri Ray Chaudhuri
申请号：
US15897688
公开号：
US20180230135A1
申请日:
2018.02.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. For example, disclosed is a compound of formula 1,wherein: R1 to R6 is selected from H, OH, CH3, OCH3, Br, Cl, Ph or o-OHC6H4, OCH2—CH═CH2, or OCH2CH2CH3, and R1 to R6 is having at least one substituent with alkyl, aryl and heteroaryl groups other than H, wherein the carbon in alkyl, aryl and heteroaryl is in the range of C1 to C8. Various embodiments relate to representative compounds of Formula 1 and method of preparation thereof. Further embodiments relates to the use of representative compounds of Formula 1 in treating diseases associated with gastric ulcer and other inflammatory diseases. A noted feature of an embodiment is the IC50 value of 50 μM of one of the 3-indolyl furanoids.
