H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE; INC.
发明人:
LIST, Alan,WEI, Sheng
申请号:
USUS2017/045140
公开号:
WO2018/026943A1
申请日:
2017.08.02
申请国别(地区):
WO
年份:
2018
代理人:
摘要:
Disclosed are compositions and methods for targeted treatment of cancers, such as TLR9-expressing cancers. In particular, molecules containing a TLR9 targeting ligand, such as a CpG oligodeoxynucleotide, that target lytic peptides to TLR9-expressing malignant cells are disclosed.Des compositions et des méthodes pour le traitement ciblé de cancers exprimant TLR9 sont divulguées. Linvention concerne en particulier des molécules contenant un ligand ciblant TLR9, tel quun oligodésoxynucléotide CpG, qui dirigent des peptides lytiques sur des cellules malignes exprimant TLR9.