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TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY
专利权人:
John Anthony Robinson;Steven J. DEMARCO;Frank Gombert;Wim Vrijbloed;Nityakalyani Srinivas;Ricardo Dias;Daniel Obrecht
发明人:
Steven J. DEMARCO,Wim Vrijbloed,Ricardo Dias,John Anthony Robinson,Nityakalyani Srinivas,Frank Gombert,Daniel Obrecht
申请号:
US14175160
公开号:
US20140187471A1
申请日:
2014.02.07
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Template-fixed β-hairpin peptidomimetics of the general formulawherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections.These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
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