Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

REICHENBACHER KATHARINA,DUGUID ROBERT J.,PHILLIPSON DOUGLAS,SIMSON JACQUELINE A.

申请号：

NZ62045810

公开号：

NZ620458A

申请日:

2010.02.03

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a reaction mixture comprising crystalline particles and a base (preferably sodium hydroxide), wherein the crystalline particles comprise at least about 96% by weight of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl-oxazolidin-2-one dihydrogen phosphate of formula (I), where R is PO(OH)2 (tedizolid phosphate / torezolid phosphate / TR-701) wherein the remainder of the crystalline particles comprises at least one compound selected from the group consisting of the formula (I&rsquo), (I&rsquo&rsquo), (I&rsquo&rsquo&rsquo) and (I&rsquo&rsquo&rsquo&rsquo).

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