The present invention provides new antiprotein peptides, as well as components and methods for treating, improving or preventing conditions related to joint Dano, including severe joint injury and arthritisLa presente invencion proporciona nuevos polipeptidos resistentes a la proteasa, asi como composiciones y metodos para tratar, mejorar o prevenir condiciones relacionadas con dano articular, incluyendo lesion aguda de articulaciones y artritis