PH 7 INJECTION SOLUTION COMPRISING AT LEAST ONE BASAL INSULIN WHICH PI IS BETWEEN 5.8 AND 8.5 AND AN AMPHIPHILIC COMPOUND CARRYING HYDROPHOBIC RADICALS
The invention relates to a composition which is physically stable in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least: - a basal insulin whose isoelectric point (pI) is between 5.8 and 8.5, and - an amphiphilic compound comprising a hydrophilic backbone HB, substituted by at least one hydrophobic radical -Hy of formula I, - and a cation salt at least divalent.[0001] L'invention concerne une composition stable physiquement sous forme d'une solution aqueuse injectable, dont le pH est compris entre 6,0 et 8,0, comprenant au moins: - une insuline basale dont le point isoélectrique (pI) est compris entre 5,8 et 8,5, et - un composé amphiphile comprenant un squelette hydrophile HB, substitué par au moins un radical hydrophobe -Hy de formule I, - et un sel de cation au moins divalent.
