Austin L. GURNEY,Inkyung Park,Fumiko Takada Axelrod
申请号：
US15849368
公开号：
US20180222958A1
申请日:
2017.12.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Polypeptides, agents, and molecules that bind lymphotoxin-beta receptor (LTβR) and/or tumor-associated antigens are disclosed. The polypeptides, agents, or molecules may include, without limitation, fusion or single-chain lymphotoxin-αββ polypeptides and homodimer and heterodimer molecules comprising the lymphotoxin-αββ polypeptides. Antibodies that specifically bind B7-H4 and P-CADHERIN are also disclosed. Also disclosed are methods of using the polypeptides, agents, molecules, or antibodies for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
