Stewart Cole,Alexander S. Pym,Roland Brosch,Priscille Brodin,Laleh Majlessi,Caroline Demangel,Claude LeClerc
申请号：
US12923432
公开号：
US20120189662A1
申请日:
2010.09.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
