YAN, XIAOQIANG,HUANG, ZHIHUA,YANG, HONGZHOU,SUN, BILL N.C.,HUANG, YULIANG
申请号：
CA2800688
公开号：
CA2800688C
申请日:
2011.05.25
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serumhalf-life and increased biologicalactivity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexesthrough the pairing of two Fc fragments viadisulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fcfragment of human IgG2, and a peptide connectingthe G-CSF monomer and the Fc fragment. The rhG-CSF can be used for thetreatment of neurological diseases.
