The present invention provides methods, as well as compositions relatedthereto, for the efficient transduction of cells using viral vectors. Theefficiency of transduction is increased by contacting the cell to betransduced with one or more molecules that bind the cell surface. Contact witha cell surface binding molecule may occur before, after, or simultaneouslywith contact between the viral vector and the cell. The transduced vectors maybe constructed to express a gene of interest, permitting the transduced cellsto be used as therapeutic and prophylactic agents.
