BABAOGLU, Kerim,BRIZGYS, Gediminas,CHA, Jake,CHEN, Xiaowu,GUO, Hongyan,HALCOMB, Randall L.,HAN, Xiaochun,HUANG, Richard,LIU, Hongtao,MCFADDEN, Ryan,MITCHELL, Michael L.,QI, Yingmei,ROETHLE, Paul A.,XU
申请号：
ES13719355
公开号：
ES2571479T3
申请日:
2013.04.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I ': ** Formula ** in which: R4 is selected from aryl, heterocycle and heteroaryl, wherein any aryl, heterocycle and heteroaryl of R4 is optionally substituted with one or more groups, each independently selected from halo, (C1-C6) alkyl, (C2-C6) alkenyl, halo (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkyl (C3-C7) cycloalkyl, -OH, -Oalkyl (C1-C6), -SH, -S-(C1-C6) alkyl, NH2, -NH (C1-C6) alkyl and -N ((C 1-C6) alkyl) 2, wherein (C1-C6) alkyl it is optionally substituted with hydroxy, -C 1-6 alkyl, cyano or oxo； A is phenyl, monocyclic heteroaryl or monocyclic heterocycle, wherein any phenyl, monocyclic heteroaryl or monocyclic heterocycle of A is optionally substituted with one or more groups Z1a, and B is aryl, heteroaryl or heterocycle, wherein any aryl, heteroaryl or heterocycle of B is optionally substituted with one or more groups Z1b； or A and B together form a bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle, wherein bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle are optionally substituted with one or more Z1b groups； Each Z1a is independently selected from halo, (C1-C3) alkyl, (C2-C3) alkenyl, (C2-C3) alkynyl, (C1-C3) haloalkyl, (C3-C7) carbocycle, heterocycle, (C1-) alkyl C3), -Oalkenyl (C2-C3), -Oalkynyl (C2-C3), -NRcRd, -NRaC (O) Ra, -C (O) ORb and -C (O) NRcRd, where any carbocycle (C3- C7) and Z1a heterocycle is optionally substituted with one or more halogen or (C1-C6) alkyl； Each Z1b is independently selected from halo, CN, (C1-C6) alkyl, alkenyl (C2-C6), alkynyl (C2-C6), haloalkyl (C1-C6), carbocycle (C3-C7), heteroaryl, heterocycle, arylalkyl (C1-C6) -, -OH, -O (C1-C6) alkyl, -Oalkenyl (C2-C6), -Oalkynyl (C2-C6), - NRcRd, -NRaC (O) Ra, -C (O) ORb and -C (O) NRcRd, wherein any (C3-C7) carbocycle and Z1b heterocycle is optionally substituted with one or more halogen or (C1-C6) alkyl； and each of Ra, Rb, Rc and Rd is independently H or (C1-C6) alkyl； or a salt thereof.Un compuesto de fórmula I': **Fórmula**
