Methods and compositions relating to Alzheimers disease are provided. Specifically, proteins that are differentially expressed in the Alzheimers disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimers disease are identified and described. Methods of diagnosis of Alzheimers disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimers disease.