Refers to a compound that includes a First and a Second polypeptide, in which: (a) the first polypeptide comprises: (i) a variable domain of a First immunoglobulin light chain (VL1) specific for a Target Protein (ii) a variable domain of heavy chain of a. NDA immunoglobulin (vh2) specific to a Second Target Protein and (iii) a Hinge region.A heavy chain Constant Region 2 (CH2) and a constant region of heavy chain 3 (CH3) and (b) the second polypeptide comprises: (i) a variable domain of the second immunoglobulin light chain (VL2) specific to the second Target Protein (ii) a PES Chain variable domain Ada the first immunoglobulin (VH1) specific for the first Target Protein in which: (i)The VL1 and VH1 Associate to form a binding site that binds to the first Protein Target (ii) The VL2 and vh2 Associate to form a binding site that is attached to the second Target Protein (iii) The Constant region of the heavy chain 2 (CH2) includes a tyrosine in the position On a threonine at position 252 and 254 glutamic acid at position 256Numbered according to Kabat EU Index and (iv) is the first Target Protein TNF alpha and the second Target Protein is IL - 23rd or the first Target Protein is il 23A and the second Target Protein TNF alpha, in which: (i) The VL1 comprising SEQ ID no: 2, the VH1 comprises SEQ ID No: 1The VL2 comprising SEQ ID no: 8 and said vh2 comprising SEQ ID no: 7 or (ii) The VL1 comprising SEQ ID no: 4 or 6, the VH1 comprising SEQ ID no: 3 or 5, the VL2 comprising SEQ ID no: 8 and said vh2 comprises SEQ ID no: 7 or (iii) The VL1 comprising SEQ ID no: 8, told VH1 compr Thus the SEQ ID no: 7, the VL2 comprising SEQ ID no: 2The vh2 comprising SEQ ID no: 1 or (iv) The VL1 comprising SEQ ID no: 8, told VH1 comprising SEQ ID no: 7, the VL2 comprising SEQ ID no: 4 or 6 and said vh2 comprising SEQ ID no: 3 or 5Se refiere a un compuesto que comprende un primer y segundo polipeptido, en el que: (A) dicho primer polipeptido comprende: (i) un dominio variable de cadena lige
