"HEAVY CHAIN VARIABLE REGIONS (" VH "), VH CHAIN SEQUENCES, NUCLEIC ACID, VECTOR, CELL, ANTIBODIES, ANTIBODY USE, ANTI-NOTCH3 ANTIBODY AND HUMAN FORM

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专利权人:

INC.;GENENTCH

发明人:

KANG LI,BIN-BING STEPHEN ZHOU,YUCHENG LI,SEK CHUNG FUNG,SANJAYA SINGH

申请号：

BRPI0719409

公开号：

BRPI0719409A2

申请日:

2007.12.17

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibits its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/