Oligonucleotides for modulation of target RNA activity

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专利权人:

Mirx Therapeutics ApS

发明人:

Moller, Thorleif

申请号：

AU2008261404

公开号：

AU2008261404B2

申请日:

2008.06.13

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention relates to oligonucleotides for modulation of targetRNA activity. Thus, the invention provides oligonucleotides that bind to microRNAbinding sites of target RNA. The oligonucleotides may activate RNase H or RNAi.In a preferred embodiment, the oligonucleotides prevents a microRNA from bindingto itsbinding site of the target RNA and thereby prevent the microRNA from regulatingthe target RNA. Such oligonucleotides have uses in research and developmentof new therapeutics.

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