Frederick Arthur Brookfield;Lisa Marie Frost;John P. TOSCANO;Andrew D. Cohen;Vincent Jacob Kalish;Stephen Martin Courtney
发明人:
John P. TOSCANO,Frederick Arthur Brookfield,Andrew D. Cohen,Stephen Martin Courtney,Lisa Marie Frost,Vincent Jacob Kalish
申请号：
US13531364
公开号：
US20120258965A1
申请日:
2012.06.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
