INDUSTRY-ACADEMIC COORPERATION FOUNDATION DAEGU HAANY UNIVERSITY;대구한의대학교산학협력단
发明人:
YANG, CHAE HA,양재하,AHN, EUN MI,안은미,KANG, JOO BONG,강주봉,CHO, HI JAE,조희재,JANG, EUN YOUNG,장은영,KIM, HONG YU,김홍유
申请号：
KR1020110077597
公开号：
KR1020130015551A
申请日:
2011.08.04
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing an Angelica dahurica extract is provided to rapidly reduce drug dependence and to be used as a pharmaceutical composition and a health functional food for preventing and treating drug addiction and the withdrawal symptom. CONSTITUTION: A pharmaceutical composition for preventing and treating drug addiction and the withdrawal symptom contains an Angelica dahurica extract as an active ingredient. The extract is a crude Angelica dahurica extract or an Angelica dahurica fraction. The crude extract is prepared using water, low alcohol of C1-C4, or a mixture thereof. The fraction includes a non-polar solvent soluble extract which is dissolved in hexane, chloroform, diethyl acetate, methylene chloride or 17 subfractions(ADE-22-13-1 to ADE-22-13-17) which are prepared from subfractions(ADE-22-13) using a silica gel column. The subfraction is prepared from the non-polar solvent soluble extract. The drug includes cocaine, methamphetamine, alcohol, nicotine, or morphine. A health functional food for preventing and treating drug addiction and the withdrawal symptom contains the extract as an active ingredient. [Reference numerals] (AA) Percentage of pressing levers about background； (BB) Physiological saline group； (CC) 100mg/kg Angelica dahurica group본 발명은 백지추출물을 유효성분으로 함유하는 조성물에 관한 것으로서, 구체적으로 본 발명의 백지추출물은 약물 중독의 지표로 사용되는 보행성 활동량, 자가 투여량 및 약물에 대한 의존성을 급격히 감소시킴을 확인함으로써, 상기 조성물은 약물 중독 및 금단증상의 예방 및 치료를 위한 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
