The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. The transcutaneous analyte sensor system 10 can include an applicator (12), a mounting unit (14), an electronics unit (16), a base (24) adapted for mounting on the skin of a host, and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).